We are the investment architects of health. Through our patient capital, we bring technology, innovative business models, and care disciplines together. The curated convergence of all three is at the core of the 4100DX investment thesis and our vision for patient-focused, tech-enabled care across all aspects of health. From physical and mental health to oral health, our investment team of seasoned operators provide entrepreneurs with capital and strategic support to design, plan, and influence the structures, systems, and solutions that shape health outcomes of the future, today.
From seed-stage ventures to strategic buyouts, we leverage our expertise to provide financial backing to innovative startups and established companies alike. We fuel their growth and facilitate the development of groundbreaking health-related products and other advancements aimed at improving global wellness.
Our investable capital base—established through both permanent capital vehicles and more traditional funds—enables us to forge enduring partnerships with visionary leaders in the industry. Together, we redefine categories, cultivate exceptional companies, and drive the development of uniquely innovative products.
We see a trend in healthcare where professionals extend their expertise beyond traditional boundaries, offering holistic services that address a broader spectrum of patient needs. This approach recognizes the interconnectedness of various health aspects, promoting comprehensive care that benefits overall well-being. Each specialist applies their unique skills to treat conditions traditionally managed outside their primary field, reflecting an integrated healthcare model focused on enhancing patient outcomes across multiple dimensions of health.
Our investments directly impact the quadruple aim and represent a balance of clinical, economic and humanistic factors in the interest of creating both immediate and future shared value. We help the builders of the future rethink how sustained value creation can come about through insight, foresight and cross-sight into the converging megatrends of predictive, personalized, preventative and participatory 21st century models of care.
Powered by patient capital, we propel the advancement of computationally-advanced platforms for drug discovery, optimization, repurposing, and delivery. Our investment in innovative hardware and software solutions fuels progress in precision medicine, diagnostics, and targeted treatments, ushering in an era of personalized and effective care for all.
Orbita develops conversational AI platforms for healthcare, enhancing patient engagement and communication while streamlining clinical workflows.
Clarapath creates automated tissue processing systems for pathology labs, focusing on the histology process to improve diagnostic efficiency.
HealthBridge provides benefit programs that bridge the gap between what insurance covers and what patients owe, making healthcare more affordable and accessible while reducing financial stress for patients and providers.
Fontana Biosciences is developing an oral therapeutic for dry eye disease.
Inflammatix creates rapid tests using machine learning-based diagnostics to identify immune response signatures for infection and sepsis detection.
Magnolia Medical Technologies develops blood collection devices to reduce contamination and improve blood culture accuracy.
VyncaCare (formerly Vynca) provides community-based palliative care services for patients with serious illnesses in a hybrid care model that combines in-home and virtual visits to improve quality of life and reduce unnecessary hospital visits.
Sensory Cloud develops innovative aerosol delivery systems for therapeutics and wellness products, including nasal hygiene solutions.
ProCredEx focuses on modernizing and streamlining the credentialing and compliance processes for healthcare professionals and organizations to reduce administrative burdens and improve efficiency.
Sana Health creates wearable devices using audio-visual stimulation for pain relief, sleep improvement, and mental wellness enhancement.
Genomenon is a genomics intelligence company that uses AI and expert curation to simplify complex genetic data for patient diagnosis and precision medicine development, offering software, data, and services to support genomic research and clinical decision-making.
Root Functional Medicine offers personalized functional medicine services, focusing on addressing the root causes of health issues through a team of doctors and dietitians who provide customized wellness plans and virtual consultations.
Joyn Health reimagines a primary care membership model that provides patients with extended physician time, holistic wellness approaches, and premium services, limiting patient loads per doctor to enhance the quality of care and overall healthcare experience.
Dyntl provides customized, tech-enabled dental clinic solutions for institutions, combining on-site or near-site facilities with digital platforms to integrate preventive oral healthcare into broader health strategies.
Proclaim (Fresh Health) offers an innovative, personalized oral cleaning system that provides a 360-degree deep clean in seven seconds.
Willo creates an innovative, automated toothbrush system for children that provides full coverage cleaning and promotes independent brushing habits through its AutoFlo+ technology and companion app.
Andros Technologies provides provider network management solutions and services for healthcare payers and providers through their proprietary data-driven platform.
Sleep Architects offers diagnostic services and treatments for sleep-related breathing disorders, including home sleep tests and oral appliance therapy, with a focus on educating patients about sleep disorders and their health impacts.
Ansel Health provides supplemental health insurance solutions designed to help employees manage unexpected medical costs that aren't fully covered by their primary health insurance, aiming to prevent health issues from becoming financial burdens.
Gauss Surgical produces AI-powered solutions for monitoring blood loss during surgery, improving patient safety.
Citizen Health leverages patient health data and shared experiences to support and empower individuals with rare and complex conditions, aiming to improve care and accelerate research for treatments and cures.
Circularis Biotech develops tools to enhance gene expression for biopharmaceutical and synthetic biology applications, with a focus on circular RNA technology.
Managing Director
Systemic Health Investor, Licensed Physician, Practice Management Expert
Venture capitalist with track record of multiple exits, board certified diagnostic radiologist, and real estate entrepreneur with extensive experience in practice management, corporate leadership, and contract negotiation.
Managing Director
Healthcare Investor, Deal Expert, Operations Leader
Experienced healthcare investor, founder with multiple exits, board member and advisor to healthcare and technology companies focused on accelerating growth and streamlining operations.
Managing Director
Systemic Health Investor, Tech Adoption Expert, Fortune 20 Executive
Seasoned Fortune 20 executive and systemic health investor, experienced in scaling category-defining products and solutions, thought-leader on integrated care, tech-enabled care delivery, new payment models, co-host of the Think Oral Health Podcast.
